Medicine. Doribax ® Doripenem 500 mg vial [Janssen-Cilag] Class: Carbapenem antibiotics NED & NC –Imipenem & Meropenem : ED ง Dosing: 500 mg iv q 8 hr.

Præsentationer af emnet: "Medicine. Doribax ® Doripenem 500 mg vial [Janssen-Cilag] Class: Carbapenem antibiotics NED & NC –Imipenem & Meropenem : ED ง Dosing: 500 mg iv q 8 hr."— Præsentationens transcript:

1 Medicine

2 Doribax ® Doripenem 500 mg vial [Janssen-Cilag] Class: Carbapenem antibiotics NED & NC –Imipenem & Meropenem : ED ง Dosing: 500 mg iv q 8 hr (1 or 4 hr infusion)

3 Maharaj NST Antibiogram 2009 Drugs Organisms LocationAMKGENCROCAZCIPLVXTZPCSLIPMMEMCL A.baumannii IPD 413923539403846484698 IPD MDR 7602776151699.5 NEO 23 25282228372732100 PED 5458124260724447504597 SUR 413703643444150494698 ORTHO 13 25927422040292593 ICU 1 282502327312527302999 ICU 2 262102220272128 2994 MED 1 302832425242734383999 MED 2+3 67 06263306170747198

4 Maharaj NST Antibiogram 2009 Drugs Organisms LocationAMKGENCROCAZCIPLVXTZPCSLIPMMEMCL P.aeruginosa IPD 827817682808871868999.9 IPD MDR 209013261870174945100 NEO 9688090100 92816591100 PED 9795096 99929697100 SUR 70680 74758565848999.5 ORTHO 86 097899092869190100 ICU 1 8072062797279568082100 ICU 2 6965125662 85736470100 MED 1 8582074858188658691100 MED 2+3 9488086928891779394100

5 Maharaj NST Antibiogram 2009 Drugs Organisms LocationAMKGENCROCAZCIPLVXTZPCSLIPMMEMCL E.coli IPD 967166794952949210099.999 NEO 87691006069100 PED 9876778576779897100 SUR 9363496828349388100 99 ORTHO 10061807946529498100 95 ICU 1 8657756243588690100 ICU 2 10067505727219373100 MED 1 976865795258949010099100 MED 2+3 977475825455959499.710099.7 E.coli ESBL+ IPD 98790030299190100 99 E.coli ESBL+ MDR IPD 855001117867199 100

6 Maharaj NST Antibiogram 2009 Drugs Organisms LocationAMKGENCROCAZCIPLVXTZPCSLIPMMEMCL K.pneumoniae IPD 9169006080667299.899.999 NEO 67370065957685100 PED 89570052896064100 SUR 88740064856976100 99 ORTHO 96640081908387100 ICU 1 76420041803456100 97 ICU 2 885200356343529810098 MED 1 94690054746062100 99 MED 2+3 9575006780778099.599.799 K.pneumoniae ESBL+ IPD 99860037645153100 99 K.pneumoniae ESBL+ MDR IPD 76500156827429999.699

7 IndicationsDoripenemImipenemMeropenem Bacterial septicemia -  Genital inf., female -  Bone & joint inf. -  - Skin & soft tissue inf. -  Intra-abdominal inf.  IE-  - LRI  (VAP)  Mixed inf.-  UTI  Meningitis--  Febrile neutropenia --  Surgical prophylaxis -  -

8 DosingDoripenemImipenemMeropenem Intra-abdo inf, complicated 500 mg iv q 8 hr 500-1000 mg iv q 6-8 hr 1000 mg iv q 8 hr LRI included VAP 500 mg iv q 8 hr 500-1000 mg iv q 6-8 hr 500-1000 mg iv q 8 hr UTI included pyelo- nephritis 500 mg iv q 8 hr 500 mg iv q 6 hr 500 mg iv q 8 hr

9 SafetyDoripenemImipenemMeropenem Pediatric useX  Dosage adjustment in renal insuff.  Dosage adjustment in hepatic insuff. XXX Pregnancy cat.BCB Phlebitis  - Diarrhea  Nausea  Anemia  -- Agranulocytosis--  Seizure  Renal failure  -

10 Cost (Baht) Cost/ unit Cost/day Cost/ treatment course 8 days (VAP) 14 days Doripenem 1273.303819.9 (500 mg iv q 8 hrs) 30559.253478.6 Imipenem 493.853950.8 (1000 mg iv q 6 hrs) 31606.455311.2 Meropenem 1198.403595.2 (1000 mg iv q 8 hrs) 28761.650332.8

11 Micromedex Healthcare Series Online MIMS Thailand Online National List of Essential Medicines 2008 Product information (package insert) References